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Association of MT2A Gene Polymorphism in the Patients Suffering from Type 2 Diabetes Mellitus and Dilated Cardiomyopathy


 
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1. Title Title of document Association of MT2A Gene Polymorphism in the Patients Suffering from Type 2 Diabetes Mellitus and Dilated Cardiomyopathy
 
2. Creator Author's name, affiliation, country Kinnari N. Mistry; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Anand, Gujarat; India
 
2. Creator Author's name, affiliation, country Sanjay lal; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Anand, Gujarat; India
 
2. Creator Author's name, affiliation, country Anjali Thakkar; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Anand, Gujarat; India
 
2. Creator Author's name, affiliation, country Avani Solanki; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Anand, Gujarat; India
 
3. Subject Discipline(s) Medical Biotechnology
 
3. Subject Keyword(s) Diabetes Mellitus, Dilated Cardiomyopathy, Metallothionein, Single Nucleotide Polymorphism
 
3. Subject Subject classification Diabetes
 
4. Description Abstract

Metallothioneins (MTs) are a group of intracellular metal-binding and cysteine-enriched proteins and are highly inducible in many tissues in response to various types of stress. The aim of the present study was to evaluate the role of MT2A gene polymorphism as a risk factor in the pathogenesis of cardiomyopathy. Molecular analysis was done in 15 patients with dilated cardiomyopathy, 20 diabetic patients without clinical evidence for cardiovascular disease. There was a significant difference between the control group and T2DM group [p value=0.048, odd ratio=3.857, 95% confidence interval (0.998-16.083)]. There was a significant difference between the control group and the dilated cardiomyopathy group [p value= 0.032, odds ratio= 4.500, 95% confidence interval (1.092-19.888)]. We found a significantly higher AA genotype frequency for MT2A in patients with CAD compared with NCVDDP patients and significantly higher AG+GG genotype frequency in diabetic patients. These finding suggest that MT2A Gene Polymorphism is associated in the patients suffering from Type 2 Diabetes Mellitus and Dilated Cardiomyopathy.

 
 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s) Contributors : Dr Kinnari N Mistry,Department of medical biotechnology , ARIBAS , [email protected], Mr. Sanjay Lal, [email protected],Ms,Anjali Thakkar,[email protected], Ms. Avani solanki,[email protected] suppoted by CVM
 
7. Date (YYYY-MM-DD) 2013-07-10
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://medical.cloud-journals.com/index.php/IJADR/article/view/Med-76
11. Source Journal/conference title; vol., no. (year) International Journal of Advanced Diabetes Research; Published Papers
 
12. Language English=en en
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
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