Association of MT2A Gene Polymorphism in the Patients Suffering from Type 2 Diabetes Mellitus and Dilated Cardiomyopathy

Abstract

Metallothioneins (MTs) are a group of intracellular metal-binding and cysteine-enriched proteins and are highly inducible in many tissues in response to various types of stress. The aim of the present study was to evaluate the role of MT2A gene polymorphism as a risk factor in the pathogenesis of cardiomyopathy. Molecular analysis was done in 15 patients with dilated cardiomyopathy, 20 diabetic patients without clinical evidence for cardiovascular disease. There was a significant difference between the control group and T2DM group [p value=0.048, odd ratio=3.857, 95% confidence interval (0.998-16.083)]. There was a significant difference between the control group and the dilated cardiomyopathy group [p value= 0.032, odds ratio= 4.500, 95% confidence interval (1.092-19.888)]. We found a significantly higher AA genotype frequency for MT2A in patients with CAD compared with NCVDDP patients and significantly higher AG+GG genotype frequency in diabetic patients. These finding suggest that MT2A Gene Polymorphism is associated in the patients suffering from Type 2 Diabetes Mellitus and Dilated Cardiomyopathy.