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Sirtuins and Aging: is there a Role for Resveratrol?


 
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1. Title Title of document Sirtuins and Aging: is there a Role for Resveratrol?
 
2. Creator Author's name, affiliation, country Caterina Carollo; Department of Internal and Specialistic Medicine, University of Palermo, Italy
 
2. Creator Author's name, affiliation, country Alberto Firenze; Department of Hygiene and Preventive Medicine, University of Palermo, Italy
 
2. Creator Author's name, affiliation, country Gregorio Caimi; Department of Internal and Specialistic Medicine, University of Palermo, Italy
 
3. Subject Discipline(s) internal medicine; clinical nutrition; ageing;
 
3. Subject Keyword(s) Resveratrol; Aging; Sirtuins
 
3. Subject Subject classification nutrition
 
4. Description Abstract

Prolonged human life duration is consequently associated with a higher incidence of chronic diseases. Aging is a very complex process in which genetic, environmental and cellular pathways are involved. Along with aging, longevity has been linked with Sirtuins. Sirtuin enzymes are a family of highly conserved protein deacetylases that have been linked with calorie restriction and aging by modulating energy metabolism, genomic stability and stress resistance. Aim of this brief review is to describe Sirtuins’ influence on the conditions that worsen the physiological aging. We will also report the beneficial effects of the polyphenol resveratrol on these molecules and the possible therapeutical perspectives.

 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2016-06-30
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://medical.cloud-journals.com/index.php/IJANHS/article/view/Med-318
11. Source Journal/conference title; vol., no. (year) International Journal of Advanced Nutritional and Health Science; Vol 4, No 1 (2016)
 
12. Language English=en en
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
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