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Aging Differentially Effects Diet-Induced Obesity and Central Leptin Sensitivity in Rats


 
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1. Title Title of document Aging Differentially Effects Diet-Induced Obesity and Central Leptin Sensitivity in Rats
 
2. Creator Author's name, affiliation, country Lynda M. Brown; Food and Nutritional Sciences Program, Department of Family and Consumer Sciences, North Carolina, Agricultural and Technical State University, Greensboro, North Carolina, USA
 
2. Creator Author's name, affiliation, country Keshia R. Ladmirault; Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina, USA
 
2. Creator Author's name, affiliation, country Paula T. Cooney; Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina, USA
 
3. Subject Discipline(s) Nutrition; Physiology; Neuroscience
 
3. Subject Keyword(s) Sex Differences; Estradiol; High-Fat Diet; Inflammation; Long Evans Rats; Visceral Fat
 
3. Subject Subject classification Obesity
 
4. Description Abstract

In this study we examined whether sex differences in central leptin sensitive young rats disappears in middle-aged rats. As animals age, many gain visceral fat and develop leptin resistance, making them more susceptible to inflammation. Middle-aged rats were fed low-fat (LF) or high-fat (HF) diets for 2 months and during this time were given intra-3rd-ventricular (i3vt) leptin injections in a range of doses. Females had a dose dependent decrease in food intake (FI) in response to i3vt leptin. Males reduced FI after i3vt injection of 5.0 μg leptin but not at any other dose. There was also a higher expression of hypothalamic cytokines that are part of the inflammation cascade in males including IL6, TNFα and XBP1. Females remained sensitive to i3vt leptin and had lower hypothalamic cytokine expression than males. The female rats in both diets had visceral fat percentages similar to that of the males which may mean that age increases fat in this depot in rats. These data indicate that middle-aged rats are in a transition period in terms of hormonal sensitivity that may serve as a model to study age-associated changes. Response patterns in female rats that are cycling but have not reached persistent estrous may be suggestive for explanations of physiological changes in perimenopausal women. These findings are important because aging represents a time when health is impacted by diet, body fat distribution and estrogen levels.

 
5. Publisher Organizing agency, location
 
6. Contributor Sponsor(s) USDA ARS grant NC06871; New Faculty Grant UNCG Office of Research and Economic Development; NCAT USDA Evans Allen Grant
 
7. Date (YYYY-MM-DD) 2016-02-22
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://medical.cloud-journals.com/index.php/IJANHS/article/view/Med-281
11. Source Journal/conference title; vol., no. (year) International Journal of Advanced Nutritional and Health Science; Vol 4, No 1 (2016)
 
12. Language English=en en
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
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