Calpain 10 Gene Polymorphism and Its Association in Cardiomyopathy and Type 2 Diabetes
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Calpain 10 Gene Polymorphism and Its Association in Cardiomyopathy and Type 2 Diabetes |
| 2. | Creator | Author's name, affiliation, country | Kinnari N. Mistry; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Gujarat; India |
| 2. | Creator | Author's name, affiliation, country | Sanjay lal; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Gujarat; India |
| 2. | Creator | Author's name, affiliation, country | Avani Solanki; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Gujarat |
| 2. | Creator | Author's name, affiliation, country | Anjali Thakkar; Department of Medical Biotechnology, Ashok and Rita Patel Institute of Integrated Study & Research in Biotechnology and Allied Sciences (ARIBAS), New Vallabh Vidyanagar, Gujarat; India |
| 3. | Subject | Discipline(s) | Diabetes, Medical Biotechnology,Human genetics,Biochemistry and Biotechnology, Molecular Marker |
| 3. | Subject | Keyword(s) | CAPN10 Gene, Single Nucleotide Polymorphism 19, Type 2 Diabetes Mellitus |
| 3. | Subject | Subject classification | Molecular Biology, Genetics,Diabetes |
| 4. | Description | Abstract |
Type 2 diabetes mellitus (T2DM) is genetically defined as a complex disease caused by the interaction of environment and genes, which are located in different regions from the human genome. Cardiomyopathy, a prominent cardiovascular complication, has been recognized as a micro vascular disease that may lead to heart failure. Calpain 10 (CAPN10) is a susceptibility gene for the disease, located in 2q37.3. Calpains are non-lysosomal calcium dependent cysteine proteases that participate in insulin secretion and action. Polymorphisms in the calpain- 10 gene have been shown to increase the risk for type 2 diabetes and cardiomyopathy. In this research, it has been postulated that SNP- 19 of CAPN10 gene was associated with T2DM and cardiomyopathy. It has been analyzed 30 diabetic patients, 20 cardiomyopathy patients and 10 healthy controls. CAPN10 SNP-19 (Insertion/deletion) polymorphism genotyping was done by PCR. The results showed association of SNP19 with T2DM (χ2 = 13.19 & p = 0.001) and cardiomyopathy (χ2 = 5.00 & p = 0.029). In conclusion, results from the present study indicate a significant association of SNP19 in CAPN10 gene to T2DM and cardiomyopathy. |
| 5. | Publisher | Organizing agency, location | |
| 6. | Contributor | Sponsor(s) | Charutur Vidhya Mandal, VV Nagar,Anand, Gujarat, India |
| 7. | Date | (YYYY-MM-DD) | 2013-07-31 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Molecular Marker |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | http://medical.cloud-journals.com/index.php/IJADR/article/view/Med-44 |
| 11. | Source | Journal/conference title; vol., no. (year) | International Journal of Advanced Diabetes Research; Published Papers |
| 12. | Language | English=en | en |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | India, Human |
| 15. | Rights | Copyright and permissions |
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