On the Role of Genomic Islands in Bacterial Pathogenicity and Antimicrobial Resistance
Dublin Core | PKP Metadata Items | Metadata for this Document | |
1. | Title | Title of document | On the Role of Genomic Islands in Bacterial Pathogenicity and Antimicrobial Resistance |
2. | Creator | Author's name, affiliation, country | Doaa Safwat Mohammad; Directorate of Health Affairs, Ministry of Health and Population, Minia, Egypt |
3. | Subject | Discipline(s) | Microbiology and Immunology |
3. | Subject | Keyword(s) | Antimicrobials; Evolution; Horizontal; Islands; Pathogenic; Resistance |
3. | Subject | Subject classification | Bacterial Genetics |
4. | Description | Abstract |
The problem of antimicrobials use failure is increasing everyday due to the transfer of virulence and antimicrobial resistance genes among different bacterial species where Genomic Islands (GEIs) have a major role. Virulence and antimicrobial resistance genes are encoded on GEIs where they can excise from a host chromosome, transfer and integrate into a new chromosome. Nonpathogenic strains become pathogenic by horizontal transfer of GEIs which in turn contributes in evolution of bacteria. GEIs was originated for symbiotic purposes then became pathogenic due changes in the environment and genes acquisition and they are useful in bacterial diagnosis as they are species-specific in some strains. The locus of enterocyte effacement (LEE) pathogenicity islands (PAIs) of Enteropathogenic E.coli (EPEC), Staphylococcus PAIs encoding toxic shock syndrome toxin (TSST), Salmonella genomic island 1(SGI1) of S. Typhimurium, the AbaR and Tn6167 GEIs of A. baumannii and the cytotoxin-associated gene (cag) and tfs4 GEIs of H. pylori are well known examples of GEIs. Target DNAs are edited by Clustered regularly interspaced short palindromic repeats (CRISPRs) and their associated (Cas) proteins causing bacterial evolution and pathogenicity. Genomic signature variation is utilized for detection of GEIs in host chromosome. |
5. | Publisher | Organizing agency, location | |
6. | Contributor | Sponsor(s) | |
7. | Date | (YYYY-MM-DD) | 2014-05-02 |
8. | Type | Status & genre | Peer-reviewed Article |
8. | Type | Type | |
9. | Format | File format | |
10. | Identifier | Uniform Resource Identifier | http://medical.cloud-journals.com/index.php/IJABB/article/view/Med-156 |
11. | Source | Journal/conference title; vol., no. (year) | International Journal of Advanced Biotechnology and Bioengineering; Published Papers |
12. | Language | English=en | en |
14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
15. | Rights | Copyright and permissions |
Copyright Terms & Conditions Authors who publish with this journal agree to the following terms: a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work Cloud Publications reserves the right to amend/change the copyright policy; with/without notice. |