Cancer is a dreadful disease. Uncontrolled growth of cells is called Cancer. First cell is formed from sperm & ovum [Shukra & Shonit]. Controlled multiple division of this cell is result of individual’s body. If this division is uncontrolled, it is cause to create Cancer. Every divided cell is producing same type of new cells. If new cell is not as it is in comparison with mother cell, it can be called cancer. It is not a new disease, ancient text of Ayurved have definite references. In Ayurved, it is described as an Arbuda, Vidradhi, Granthi, Gulma, Shoth and Apachi etc. As per etiology of Ayurved Shoth is primary symptom of Cancer. Because of diminished Jatharagani and Dhatvagni aamotpati takes place. The sthanashanshraya stage is the base of uncontrolled growth. Specific Dhatvagnimandhya is result of specific dhatu’s abnormal vridhi or uncontrolled growth. According to Ayurvedic texts, cancer is a serious Dhatugat disease. So, shodhana chikitsa is required as per condition of disease and patient. Raktamokshan (Bloodletting), Shalya Karma (Surgery) and Agnikarma (Heat Burn therapy) are especially beneficial in this disease. Following drugs are useful for internal use – Kanchnar, Gokshure, Nirgundi, Punarnava, Bhumyamalaki, Bhalataka, Ashwagandha, Ahiphen, Rohitak, Hirak Bhasma, Suvarna Bhasma, Tamra Bhasma, Shringa Bhasma, Abhraka Bhasma etc. There is a definite need to use these drugs in various formulations to establish therapeutic efficacy to conquer this challenging disease.