With the nature of diseased state life portrait get changed bringing change state. We can make better application of these lesser known medicine when we apply in consideration with the available symptoms in them with rational search for related aspects through the hypothetical understanding created to bring a complete meaning for the prescribed medicine. This study is to search for the lesser known medicines as presented in our Repertory and Materia Medica. There are the wide ranges of Homoeopathic medicines considered as rare remedies on the basis of Paucity of symptoms and Large medicines with rare symptoms representing the uniqueness when selected on the basis of totality inclusion. Homoeopathic clinical approach requires understanding for these of its broad range of medicines belonging to both large and lesser group of medicines. Use of rare medicines is required as management during the acute stages as well as in one sided presentation of symptoms in such cases.