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Antioxidant Evaluation of Romasanjanana Lepa- A Compound Formulation for Indralupta


 
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1. Title Title of document Antioxidant Evaluation of Romasanjanana Lepa- A Compound Formulation for Indralupta
 
2. Creator Author's name, affiliation, country Deodatta Bhadalikar; D.Y. Patil University, School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, India
 
2. Creator Author's name, affiliation, country Lavekar G.S.; CCRAS, Department of Shalyatantra, New Delhi, India
 
2. Creator Author's name, affiliation, country Rasika Kolhe; Department of Dravyaguna Vijnana, D.Y. Patil University, School of Ayurveda, Nerul, Navi Mumbai, Maharashtra, India
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Antioxidant; Indralupta; Romasanjanan Lepa
 
4. Description Abstract

Alopecia Areata (AA) is the common form of hair loss affecting the quality of life of many patients. In Ayurved, loss of hair is coined as ‘Indralupta’ described in Kshudra Rogas. Vata Pitta Kapha Dosha along with the vitiation of Rakta is responsible for pathophysiology of Indralupta whereas, according to modern science, Alopecia areata is a tissue-restricted autoimmune disease. Therefore it is important to evaluate the role of antioxidant in the treatment. Ayurveda has advocated Lepa in Indralupta. Therefore a compound formulation consisting of leaf of Karanja, fruit of Kapittha, Kasisa and Hastidant Mashi was formulated following standard guideline. To evaluate the antioxidant activity in the compound formulation, it was subjected to Total phenolic content by Folin’s reagent, Antioxidant by DPPH(1,1-diphenyl-2-picrylhydrazyl), Antioxidant by FRAP (ferric reducing antioxidant power), total flavonoid content, and assessment of phenolic compound by HPLC method on distilled water, methanolic and ethanolic extract of the formulation. Result of the study showed maximum Total phenolic content in distilled water extract, whereas total flavonoid was maximum in methanolic extract, Antioxidant by DPPH was maximum (85.24±0.30) in distilled water extract. Whereas by FRAP method, it was maximum (0.017±0.02) in methanolic extract. Total phenolic content was highest in ethanolic extract.

 
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7. Date (YYYY-MM-DD) 2015-10-24
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier http://medical.cloud-journals.com/index.php/IJAAYUSH/article/view/Med-261
11. Source Journal/conference title; vol., no. (year) International Journal of Advanced Ayurveda, Yoga, Unani, Siddha and Homeopathy; Vol 4, No 1 (2015)
 
12. Language English=en en
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
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